Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation-Reference-Cited by-同舟云学术

Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation

Published:2019-07-23 Issue:591 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Jun Jesse E.¹^ORCID,Kulhanek Kayla R.¹^ORCID,Chen Hang²,Chakraborty Arup²^ORCID,Roose Jeroen P.¹^ORCID

Affiliation:

1. Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.

2. Departments of Chemical Engineering, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Abstract

“Alternative” ZAP70–dependent activation of the kinase p38 increases activation of the “classical” p38 cascade in T cells.

Funder

NIH

NIH NIAID

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference85 articles.

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4. Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

5. The p38 mitogen-activated protein kinase regulates effector functions of primary human CD4 T cells

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