Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gα i -GTP and Gβγ-Reference-Cited by-同舟云学术

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Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gα i -GTP and Gβγ

Published:2016-02-23 Issue:416 Volume:9 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Surve Chinmay R.¹,To Jesi Y.²,Malik Sundeep²,Kim Minsoo³,Smrcka Alan V.¹²

Affiliation:

1. Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA.

2. Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA.

3. Department of Immunology and Microbiology, University of Rochester, Rochester, NY 14642, USA.

Abstract

Opposing effects of G i protein α and βγ subunits on the abundance of the second messenger cAMP enable neutrophil migration.

Funder

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference45 articles.

1. Cell Migration: A Physically Integrated Molecular Process

2. Random versus directionally persistent cell migration

3. A Cell's Sense of Direction

4. Dynamics of a Chemoattractant Receptor in Living Neutrophils during Chemotaxis

5. Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

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