Targeting ischemia-induced KCC2 hypofunction rescues refractory neonatal seizures and mitigates epileptogenesis in a mouse model-Reference-Cited by-同舟云学术

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Targeting ischemia-induced KCC2 hypofunction rescues refractory neonatal seizures and mitigates epileptogenesis in a mouse model

Published:2021-11-09 Issue:708 Volume:14 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sullivan Brennan J.¹^ORCID,Kipnis Pavel A.¹^ORCID,Carter Brandon M.¹^ORCID,Shao Li-Rong²^ORCID,Kadam Shilpa D.¹³^ORCID

Affiliation:

1. Neuroscience Laboratory, Hugo Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA.

2. Division of Pediatric Neurology, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

3. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

The drug CLP290 may treat neonatal seizures by acutely enhancing the function of K + /Cl − cotransporter KCC2.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference75 articles.

1. J. Volpe T. Inder B. Darras L. de Vries A. du Plessis J. Neill J. Perlman Volpe’s Neurology of the Newborn (Elsevier ed. 6 2017).

2. Neonatal seizures

3. Response to antiseizure medications in neonates with acute symptomatic seizures

4. Monitoring neonatal seizures

5. Cation-chloride cotransporters in neuronal development, plasticity and disease

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1. New epilepsy therapies in development;Nature Reviews Drug Discovery;2024-07-22

2. The suppressive effect of the specific KCC2 modulator CLP290 on seizure in mice;Epilepsy Research;2024-07

3. Peripheral Blood Mononuclear Cell Expression of Cation-Chloride Cotransporter (CCC) Genes in Premenstrual Dysphoric Disorder (PMDD) across the Menstrual Cycle—A Preliminary Study;Biology;2024-05-25

4. Combination administration of alprazolam and N-Ethylmaleimide synergistically enhances sleep behaviors in mice with no potential CNS side effects;PeerJ;2024-05-07

5. The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal Cl− extrusion;iScience;2024-04

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