The mTORC1/4E-BP pathway coordinates hemoglobin production with L -leucine availability-Reference-Cited by-同舟云学术

The mTORC1/4E-BP pathway coordinates hemoglobin production with L -leucine availability

Published:2015-04-14 Issue:372 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Chung Jacky¹,Bauer Daniel E.²³,Ghamari Alireza²³,Nizzi Christopher P.⁴,Deck Kathryn M.⁴,Kingsley Paul D.⁵,Yien Yvette Y.¹,Huston Nicholas C.¹,Chen Caiyong¹,Schultz Iman J.¹,Dalton Arthur J.¹,Wittig Johannes G.¹,Palis James⁵,Orkin Stuart H.²³,Lodish Harvey F.⁶,Eisenstein Richard S.⁴,Cantor Alan B.²³,Paw Barry H.¹²³

Affiliation:

1. Division of Hematology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Division of Hematology-Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

3. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

4. Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.

5. Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY 14642, USA.

6. Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Abstract

Inadequate leucine uptake by maturing red blood cells limits the production of hemoglobin.

Funder

Canadian Institutes of Health Research

Cooley's Anemia Foundation

Dutch National Science Fund-NWO

American Heart Association

March of Dimes Foundation

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference105 articles.

1. Cohesin Proteins Promote Ribosomal RNA Production and Protein Translation in Yeast and Human Cells

2. The Autistic Neuron: Troubled Translation?

3. Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo

4. Stimulation of mTORC1 with L-leucine Rescues Defects Associated with Roberts Syndrome

5. Retention and Loss of Amino Acid Biosynthetic Pathways Based on Analysis of Whole-Genome Sequences

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