Genetic evidence that β-arrestins are dispensable for the initiation of β 2 -adrenergic receptor signaling to ERK

Author:

O’Hayre Morgan1ORCID,Eichel Kelsie2,Avino Silvia13,Zhao Xuefeng145ORCID,Steffen Dana J.4,Feng Xiaodong14ORCID,Kawakami Kouki6,Aoki Junken67,Messer Karen4,Sunahara Roger4,Inoue Asuka68,von Zastrow Mark29ORCID,Gutkind J. Silvio14ORCID

Affiliation:

1. Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20852, USA.

2. Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA.

3. Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Rende (CS), Italy.

4. Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

5. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

6. Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi 980-8578, Japan.

7. Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology, Chiyoda-ku, Tokyo 100-0004, Japan.

8. Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology, Kawaguchi, Saitama 332-0012, Japan.

9. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.

Abstract

Ligand activation of β 2 -adrenergic receptors induces the phosphorylation of the kinase ERK in a β-arrestin–independent manner.

Funder

National Institute on Drug Abuse

National Institute of General Medical Sciences

National Institute of Dental and Craniofacial Research

Japan Science and Technology Agency

Precursory Research for Embryonic Science and Technology

UCSD Moores Cancer Center and Department of Pharmacology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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