Multifaceted Activities of Type I Interferon Are Revealed by a Receptor Antagonist-Reference-Cited by-同舟云学术

Multifaceted Activities of Type I Interferon Are Revealed by a Receptor Antagonist

Published:2014-05-27 Issue:327 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Levin Doron¹,Schneider William M.²,Hoffmann Hans-Heinrich²,Yarden Ganit¹,Busetto Alberto Giovanni³,Manor Ohad⁴,Sharma Nanaocha¹,Rice Charles M.²,Schreiber Gideon¹

Affiliation:

1. Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.

2. Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, NY 10065, USA.

3. Automatic Control Laboratory, ETH Zurich, 8092 Zurich, Switzerland.

4. Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

Abstract

A variant of type I interferon stimulates expression of only those genes required for an antiviral response.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference69 articles.

1. The interferon response circuit: Induction and suppression by pathogenic viruses

2. Mechanisms of type-I- and type-II-interferon-mediated signalling

3. Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation

4. Review: IFN-α/βReceptor Interactions to Biologic Outcomes: Understanding the Circuitry

5. HOW CELLS RESPOND TO INTERFERONS

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