TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis-Reference-Cited by-同舟云学术

TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis

Published:2021-06-22 Issue:688 Volume:14 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Uribe Mary L.¹^ORCID,Dahlhoff Maik²^ORCID,Batra Rajbir N.³⁴^ORCID,Nataraj Nishanth B.¹^ORCID,Haga Yuya¹⁵^ORCID,Drago-Garcia Diana¹^ORCID,Marrocco Ilaria¹,Sekar Arunachalam¹,Ghosh Soma¹,Vaknin Itay¹,Lebon Sacha¹,Kramarski Lior¹,Tsutsumi Yasuo⁵⁶,Choi Inpyo⁷^ORCID,Rueda Oscar M.³⁸^ORCID,Caldas Carlos³^ORCID,Yarden Yosef¹^ORCID

Affiliation:

1. Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.

2. Institute of in vivo and in vitro Models, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.

3. Department of Oncology and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK.

4. Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

5. Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.

6. Global Center for Medical Engineering and Informatics, Osaka University, Osaka 565-0871, Japan.

7. Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 306-809, South Korea.

8. MRC Biostatistics Unit, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0RE, UK.

Abstract

Examination of genes repressed hours after exposure to the growth factor EGF reveals that TSHZ2 restricts mitosis.

Funder

Israel Cancer Research Fund

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

University of Kentucky

Horizon 2020 Framework Programme

Cancer Research UK

European Research Council

Israel Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference89 articles.

1. Variation in cancer risk among tissues can be explained by the number of stem cell divisions

2. Microenvironmental regulation of cancer development

3. Macrophages and Metabolism in the Tumor Microenvironment

4. Hallmarks of Cancer: The Next Generation

5. Contextual determinants of TGFβ action in development, immunity and cancer

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. MerTK Drives Proliferation and Metastatic Potential in Triple-Negative Breast Cancer;International Journal of Molecular Sciences;2024-05-08

2. The CD4 T cell epigenetic JUNB+ state is associated with proliferation and exhaustion;2024-01-05

3. Prediction of myeloid malignant cells in Fanconi anemia using machine learning;2024-01-02

4. Cell-Free Genic Extrachromosomal Circular DNA Profiles of DNase Knockouts Associated with Systemic Lupus Erythematosus and Relation with Common Fragile Sites;Biomedicines;2023-12-28

5. PROS1, a clinical prognostic biomarker and tumor suppressor, is associated with immune cell infiltration in breast cancer: A bioinformatics analysis combined with experimental verification;Cellular Signalling;2023-12