FZD 5 is a Gα q -coupled receptor that exhibits the functional hallmarks of prototypical GPCRs

Author:

Wright Shane C.12ORCID,Cañizal Maria Consuelo Alonso34ORCID,Benkel Tobias5ORCID,Simon Katharina5,Le Gouill Christian2ORCID,Matricon Pierre6ORCID,Namkung Yoon7ORCID,Lukasheva Viktoria2ORCID,König Gabriele M.5,Laporte Stéphane A.78ORCID,Carlsson Jens6,Kostenis Evi5ORCID,Bouvier Michel2ORCID,Schulte Gunnar1ORCID,Hoffmann Carsten34ORCID

Affiliation:

1. Section of Receptor Biology and Signaling, Department of Physiology and Pharmacology, Karolinska Institutet, S17165 Stockholm, Sweden.

2. Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, University of Montréal, Montréal, QC H3C 3J7, Canada.

3. Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Strasse 9, 97078 Würzburg, Germany.

4. Institute for Molecular Cell Biology, CMB-Center for Molecular Biomedicine, University Hospital Jena, Friedrich-Schiller University Jena, Hans-Knöll-Strasse 2, 07745 Jena, Germany.

5. Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.

6. Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, P.O. Box 596, SE-751 24 Uppsala, Sweden.

7. Department of Medicine, Research Institute of the McGill University Health Center, McGill University, Montréal, QC H4A 3J1, Canada.

8. Department of Pharmacology and Therapeutics, McGill University, Montréal, QC H3G 1Y6, Canada.

Abstract

Ligand binding induces conformational changes in FZD 5 , activation of heterotrimeric G proteins, and G q -dependent signaling.

Funder

FP7 People: Marie-Curie Actions

Deutsche Forschungsgemeinschaft

Cancerfonden

Novo Nordisk

Stiftelsen Olle Engkvist Byggmästare

Vetenskapsrådet

Knut och Alice Wallenbergs Stiftelse

Svenska Sällskapet för Medicinsk Forskning

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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