Myeloma cells shift osteoblastogenesis to adipogenesis by inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells-Reference-Cited by-同舟云学术

Myeloma cells shift osteoblastogenesis to adipogenesis by inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells

Published:2020-05-26 Issue:633 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Liu Zhiqiang¹²³^ORCID,Liu Huan¹⁴^ORCID,He Jin¹⁴,Lin Pei⁵^ORCID,Tong Qiang⁶^ORCID,Yang Jing¹⁴^ORCID

Affiliation:

1. Department of Lymphoma and Myeloma, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

2. Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases, School of Basic Medical Science, Tianjin Medical University, Tianjin, China.

3. Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China.

4. Center for Hematologic Malignancy, Research Institute Houston Methodist Hospital, Houston, TX 77030, USA.

5. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

6. Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Myeloma cells repress osteoblastogenesis by inhibiting the degradation of PPARγ2 in mesenchymal stem cells.

Funder

American Cancer Society

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference46 articles.

1. Myeloma Bone Disease: Update on Pathogenesis and Novel Treatment Strategies

2. Osteoblast suppression in multiple myeloma bone disease

3. Multiple myeloma bone disease: pathophysiology of osteoblast inhibition

4. p38 MAPK in Myeloma Cells Regulates Osteoclast and Osteoblast Activity and Induces Bone Destruction

5. Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma

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