A Cancer-Associated Mutation in Atypical Protein Kinase Cι Occurs in a Substrate-Specific Recruitment Motif-Reference-Cited by-同舟云学术

A Cancer-Associated Mutation in Atypical Protein Kinase Cι Occurs in a Substrate-Specific Recruitment Motif

Published:2013-09-17 Issue:293 Volume:6 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Linch Mark¹²,Sanz-Garcia Marta¹,Soriano Erika³,Zhang Yixiao¹,Riou Philippe¹,Rosse Carine¹,Cameron Angus¹,Knowles Phillip³,Purkiss Andrew³,Kjaer Svend³,McDonald Neil Q.³⁴,Parker Peter J.¹⁵

Affiliation:

1. Protein Phosphorylation Laboratory, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.

2. Sarcoma Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

3. Structural Biology Laboratory, Cancer Research UK, London WC2A 3LY, UK.

4. Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK.

5. Division of Cancer Studies, King’s College London, Guy’s Hospital, London SE1 1UL, UK.

Abstract

A cancer-associated mutation in protein kinase Cι selectively disrupts epithelial polarity by inhibiting the binding of specific substrates.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference74 articles.

1. A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.

2. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

3. The interaction of p62 with RIP links the atypical PKCs to NF-kappa B activation

4. aPKC Acts Upstream of PAR-1b in Both the Establishment and Maintenance of Mammalian Epithelial Polarity

5. Atypical PKC contributes to poor prognosis through loss of apical-basal polarity and Cyclin E overexpression in ovarian cancer

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