A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways-Reference-Cited by-同舟云学术

A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways

Published:2014-05-13 Issue:325 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Morton Stephen W.¹²,Lee Michael J.¹³,Deng Zhou J.¹,Dreaden Erik C.¹,Siouve Elise¹,Shopsowitz Kevin E.¹,Shah Nisarg J.¹,Yaffe Michael B.¹³⁴,Hammond Paula T.¹²⁵

Affiliation:

1. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

2. Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA.

3. Department of Biology and Biological Engineering, MIT, Cambridge, MA 02139, USA.

4. Division of Acute Care Surgery, Trauma, and Critical Care, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

5. Institute for Soldier Nanotechnologies, MIT, Cambridge, MA 02139, USA.

Abstract

Nanoparticles containing two drugs released at different times effectively kill tumor cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference29 articles.

1. R. A. Weinberg The Biology of Cancer (Garland Science Taylor & Francis Group LLC New York 2007) p. 864.

2. Hallmarks of Cancer: The Next Generation

3. Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

4. Systems biology and combination therapy in the quest for clinical efficacy

5. Where is the hope for drug discovery? Let history tell the future

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