Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca 2+ signaling during T cell activation-Reference-Cited by-同舟云学术

Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca 2+ signaling during T cell activation

Published:2021-11-16 Issue:709 Volume:14 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Gu Feng¹^ORCID,Krüger Aileen¹^ORCID,Roggenkamp Hannes G.¹^ORCID,Alpers Rick¹,Lodygin Dmitri²,Jaquet Vincent³,Möckl Franziska¹^ORCID,Hernandez C. Lola C.¹^ORCID,Winterberg Kai¹^ORCID,Bauche Andreas¹,Rosche Anette¹,Grasberger Helmut⁴,Kao John Y.⁴^ORCID,Schetelig Daniel⁵^ORCID,Werner René⁵^ORCID,Schröder Katrin⁶^ORCID,Carty Michael⁷,Bowie Andrew G.⁷,Huber Samuel⁸^ORCID,Meier Chris⁹^ORCID,Mittrücker Hans-Willi¹⁰^ORCID,Heeren Joerg¹^ORCID,Krause Karl-Heinz³^ORCID,Flügel Alexander²,Diercks Björn-Philipp¹^ORCID,Guse Andreas H.¹^ORCID

Affiliation:

1. Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

2. Institute for Neuroimmunology and Multiple Sclerosis Research, University Medical Center Göttingen, 37075 Göttingen, Germany.

3. Department of Pathology and Immunology, University of Geneva, 1211 Geneva 4, Switzerland.

4. Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA.

5. Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.

6. Institute of Cardiovascular Physiology, Goethe-Universität, 60590 Frankfurt, Germany.

7. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

8. Department of Gastroenterology with Sections Infectiology and Tropical Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

9. Organic Chemistry, University of Hamburg, 20146 Hamburg, Germany.

10. Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Abstract

The enzymes DUOX1 and DUOX2 may mediate rapid and then sustained NAADP production to promote Ca 2+ signaling in T cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference47 articles.

1. Frontrunners of T cell activation: Initial, localized Ca 2+ signals mediated by NAADP and the type 1 ryanodine receptor

2. ORAI1, STIM1/2, and RYR1 shape subsecond Ca 2+ microdomains upon T cell activation

3. Second Messenger Function of Nicotinic Acid Adenine Dinucleotide Phosphate Revealed by an Improved Enzymatic Cycling Assay

4. HN1L/JPT2: A signaling protein that connects NAADP generation to Ca 2+ microdomain formation

5. Essential requirement for JPT2 in NAADP-evoked Ca 2+ signaling

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