Frontrunners of T cell activation: Initial, localized Ca 2+ signals mediated by NAADP and the type 1 ryanodine receptor-Reference-Cited by-同舟云学术

Frontrunners of T cell activation: Initial, localized Ca 2+ signals mediated by NAADP and the type 1 ryanodine receptor

Published:2015-10-13 Issue:398 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Wolf Insa M. A.¹,Diercks Björn-Philipp¹,Gattkowski Ellen¹,Czarniak Frederik¹,Kempski Jan¹,Werner René²,Schetelig Daniel²,Mittrücker Hans-Willi³,Schumacher Valéa³,von Osten Manuel⁴⁵,Lodygin Dimitri⁴⁵,Flügel Alexander⁴⁵,Fliegert Ralf¹,Guse Andreas H.¹

Affiliation:

1. The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

2. Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

3. Department of Immunology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

4. Institute for Multiple Sclerosis Research, Department of Neuroimmunology, Gemeinnützige Hertie-Stiftung and University Medical Center Göttingen, Waldweg 33, 37073 Göttingen, Germany.

5. Max-Planck-Institute for Experimental Medicine, Hermann-Rein-Straße 3, 37075 Göttingen, Germany.

Abstract

High-resolution imaging of live T cells characterizes the early Ca 2+ signals required for T cell activation.

Funder

Deutsche Forschungsgemeinschaft

Forschungszentrum Medizintechnik Hamburg

Forderfonds Medizin of the University Medical Center Hamburg-Eppendorf

Hertie Foundation

Landesforschungsforderung of the City of Hamburg

Publisher

American Association for the Advancement of Science (AAAS)

Subject