Mutation-induced remodeling of the BfmRS two-component system in Pseudomonas aeruginosa clinical isolates

Author:

Cao Qiao12ORCID,Yang Nana2,Wang Yanhui2,Xu Chenchen2,Zhang Xue2,Fan Ke2,Chen Feifei12ORCID,Liang Haihua1,Zhang Yingchao3ORCID,Deng Xin3ORCID,Feng Youjun4ORCID,Yang Cai-Guang25,Wu Min6ORCID,Bae Taeok7ORCID,Lan Lefu1258ORCID

Affiliation:

1. College of Life Science, Northwest University, Xi’an 710127, China.

2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

3. Department of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong 999077, China.

4. School of Medicine, Zhejiang University, Hangzhou 310058, China.

5. School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China.

6. Department of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58203-9037, USA.

7. Department of Microbiology and Immunology, Indiana University School of Medicine-Northwest, Gary, IN 46408, USA.

8. NMPA Key Laboratory for Testing Technology of Pharmaceutical Microbiology, Shanghai Institute for Food and Drug Control, Shanghai, China.

Abstract

Pseudomonas aeruginosa mutations associated with chronic infection rewire two-component signaling.

Funder

Science and Technology Commission of Shanghai Municipality

MOST of China

NSFC of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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