Generation of specific inhibitors of SUMO-1– and SUMO-2/3–mediated protein-protein interactions using Affimer (Adhiron) technology-Reference-Cited by-同舟云学术

Generation of specific inhibitors of SUMO-1– and SUMO-2/3–mediated protein-protein interactions using Affimer (Adhiron) technology

Published:2017-11-14 Issue:505 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Hughes David J.¹²^ORCID,Tiede Christian¹³^ORCID,Penswick Natalie¹,Tang Anna Ah-San¹³^ORCID,Trinh Chi H.¹⁴,Mandal Upasana¹³^ORCID,Zajac Katarzyna Z.³^ORCID,Gaule Thembaninskosi⁴^ORCID,Howell Gareth¹^ORCID,Edwards Thomas A.¹⁴,Duan Jianxin⁵,Feyfant Eric⁶^ORCID,McPherson Michael J.¹³⁴^ORCID,Tomlinson Darren C.¹³⁴^ORCID,Whitehouse Adrian¹⁴^ORCID

Affiliation:

1. School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

2. Biomedical Sciences Research Complex, University of St. Andrews, St. Andrews KY16 9ST, UK.

3. BioScreening Technology Group, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

4. Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

5. Schrödinger GmbH, Mannheim, Germany.

6. Schrödinger Inc., Cambridge, MA 02142, USA.

Abstract

Artificial binding proteins are tools for exploring cellular processes dependent on SUMOylation.

Funder

Wellcome Trust

Biotechnology and Biological Sciences Research Council

University Of Leeds

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference60 articles.

1. Human protein–protein interaction networks and the value for drug discovery

2. The druggable genome

3. PAPTi: A Peptide Aptamer Interference Toolkit for Perturbation of Protein-Protein Interaction Networks

4. A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain

5. Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies

Cited by 44 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Affimer reagents as tool molecules to modulate platelet GPVI-ligand interactions and specifically bind GPVI dimer;Blood Advances;2024-07-25

2. Generation of antibodies to an extracellular region of the transporters Glut1/Glut4 by immunization with a designed antigen;Journal of Biological Chemistry;2024-02

3. “Affimer” synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation;Journal of Biological Chemistry;2023-11

4. Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition;Cell Reports;2023-10

5. Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus;eLife;2023-05-25