2′3′-cGAMP triggers a STING- and NF-κB–dependent broad antiviral response in Drosophila-Reference-Cited by-同舟云学术

2′3′-cGAMP triggers a STING- and NF-κB–dependent broad antiviral response in Drosophila

Published:2020-12 Issue:660 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Cai Hua¹²^ORCID,Holleufer Andreas³,Simonsen Bine³^ORCID,Schneider Juliette²,Lemoine Aurélie²,Gad Hans Henrik³^ORCID,Huang Jingxian¹^ORCID,Huang Jieqing¹,Chen Di¹^ORCID,Peng Tao¹^ORCID,Marques João T.⁴⁵^ORCID,Hartmann Rune³^ORCID,Martins Nelson E.²^ORCID,Imler Jean-Luc¹²^ORCID

Affiliation:

1. Sino-French Hoffmann Institute, State Key Laboratory of Respiratory Disease, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China.

2. Université de Strasbourg, CNRS UPR 9022, 67084 Strasbourg, France.

3. Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.

4. Université de Strasbourg, CNRS UPR 9022, INSERM U1257, 67084 Strasbourg, France.

5. Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais CEP 31270901, Brazil.

Abstract

The cyclic dinucleotide 2′3′-cGAMP activates STING and NF-κB to protect Drosophila against multiple viruses.

Funder

Agence Nationale de la Recherche

Novo Nordisk Fonden

Natural Science Foundation of Guangdong Province

Chinese National Overseas Expertise Introduction Center for Discipline Innovation

Science and Technology Planning Project of Guangzhou

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry