Regulation of Epidermal Growth Factor Receptor Trafficking by Lysine Deacetylase HDAC6

Author:

Lissanu Deribe Yonathan1,Wild Philipp1,Chandrashaker Akhila2,Curak Jasna3,Schmidt Mirko H. H.14,Kalaidzidis Yannis25,Milutinovic Natasa3,Kratchmarova Irina6,Buerkle Lukas37,Fetchko Michael J.3,Schmidt Philipp1,Kittanakom Saranya3,Brown Kevin R.8,Jurisica Igor8910,Blagoev Blagoy6,Zerial Marino2,Stagljar Igor3,Dikic Ivan11112

Affiliation:

1. Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University School of Medicine, Theodor-Stern-Kai 7, D-60590 Frankfurt (Main), Germany.

2. Max-Planck-Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.

3. Departments of Biochemistry and Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, 160 College Street, Room 1204, Toronto, Ontario, Canada M5S 3E1.

4. Laboratory for Tumor Biochemistry, Institute of Neurology (Edinger Institute), Goethe University School of Medicine, Heinrich-Hoffmann-Strasse 7, D-60528 Frankfurt (Main), Germany.

5. N. Belozersky Institute of Physico-Chemical Biology, Building A, Moscow State University, Moscow 119899, Russia.

6. Center for Experimental Bioinformatics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.

7. Institute of Plant Science, ETH Zurich, CH-8092 Zurich, Switzerland.

8. Division of Signaling Biology, Ontario Cancer Institute, Princess Margaret Hospital–University Health Network, 101 College Street, Toronto Medical Discovery Tower, 9-305, Toronto, Ontario, Canada M5G 1L7.

9. Department of Computer Science, University of Toronto, Toronto, Ontario, Canada M5S 1A4.

10. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2M9.

11. Tumor Biology Program, Mediterranean Institute for Life Sciences, Mestrovicevo setaliste bb, 21000 Split, Croatia.

12. Department of Immunology, School of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia.

Abstract

HDAC6 sets a brake that slows down the delivery of activated epidermal growth factor receptors to the degradative compartment.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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