Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species-Reference-Cited by-同舟云学术

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

Published:2017-12-05 Issue:508 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Muttenthaler Markus¹²^ORCID,Andersson Åsa¹^ORCID,Vetter Irina¹³,Menon Rohit⁴,Busnelli Marta⁵⁶,Ragnarsson Lotten¹^ORCID,Bergmayr Christian⁷,Arrowsmith Sarah⁸^ORCID,Deuis Jennifer R.¹,Chiu Han Sheng¹^ORCID,Palpant Nathan J.¹,O’Brien Margaret⁹^ORCID,Smith Terry J.⁹^ORCID,Wray Susan⁸,Neumann Inga D.⁴,Gruber Christian W.⁷¹⁰^ORCID,Lewis Richard J.¹^ORCID,Alewood Paul F.¹^ORCID

Affiliation:

1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.

2. Faculty of Chemistry, Institute of Biological Chemistry, University of Vienna, 1090 Vienna, Austria.

3. School of Pharmacy, The University of Queensland, Brisbane, Queensland 4104, Australia.

4. Department of Behavioral and Molecular Neurobiology, Regensburg Center of Neuroscience, University of Regensburg, 93053 Regensburg, Germany.

5. CNR–Institute of Neuroscience, 20129 Milan, Italy.

6. Department of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy.

7. Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.

8. Department of Cellular and Molecular Physiology, Harris-Wellbeing Preterm Birth Centre, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, UK.

9. National Centre for Biomedical Engineering Science, National University of Ireland, Galway H91 CF50, Ireland.

10. School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4072, Australia.

Abstract

An oxytocin derivative that may not trigger adverse side effects has been generated.

Funder

Australian Research Council

National Health and Medical Research Council

Vienna Science and Technology Fund

Umberto Veronesi Foundation Fellow

European Union Seventh Framework Program

Marie Curie Actions

Secretary of Universities and Research of the Economy and Knowledge Department of the Government of Catalonia

Harris-Wellbeing Centre for Preterm research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference110 articles.

1. Cell-Specific Gene Expression in Oxytocin and Vasopressin Magnocellular Neurons

2. Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication

3. Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.

4. Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain

5. The Oxytocin Receptor System: Structure, Function, and Regulation

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