Site-selective <i>S-gem</i>-difluoroallylation of unprotected peptides with 3,3-difluoroallyl sulfonium salts-Reference-Cited by-同舟云学术

Site-selective S-gem-difluoroallylation of unprotected peptides with 3,3-difluoroallyl sulfonium salts

Published:2024 Issue:26 Volume:15 Page:10002-10009
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ren Jin-Xiu¹,Zhou Minqi¹,Feng Xiao-Tian¹,Zhao Hai-Yang¹,Fu Xia-Ping¹,Zhang Xingang¹²^ORCID

Affiliation:

1. Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

2. School of Chemistry and Material Sciences Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China

Abstract

Bench-stable 3,3-difluoroallyl sulfonium salts proved to be versatile fluoroalkylating reagents for site-selective S-gem-difluoroallylation of cysteine residues in unprotected peptides. The newly added functional groups are poised for ligation.

Funder

National Key Research and Development Program of China

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC02681K

Reference59 articles.

1. Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

2. Contribution of Organofluorine Compounds to Pharmaceuticals

3. Biological Utility of Fluorinated Compounds: from Materials Design to Molecular Imaging, Therapeutics and Environmental Remediation

4. Difluoromethylation of Unactivated Alkenes Using Freon-22 through Tertiary Amine-Borane-Triggered Halogen Atom Transfer

5. Fluoropolymers in biomedical applications: state-of-the-art and future perspectives

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