PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes-Reference-Cited by-同舟云学术

PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes

Published:2011-04-12 Issue:168 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Kulkarni Suhasini¹,Sitaru Cassian²³,Jakus Zoltan⁴,Anderson Karen E.¹,Damoulakis George¹,Davidson Keith¹,Hirose Misa²,Juss Jatinder¹,Oxley David¹,Chessa Tamara A. M.¹,Ramadani Faruk⁵,Guillou Herve¹,Segonds-Pichon Anne¹,Fritsch Anja⁶,Jarvis Gavin E.⁷,Okkenhaug Klaus⁵,Ludwig Ralf²,Zillikens Detlef²,Mocsai Attila⁴,Vanhaesebroeck Bart⁸,Stephens Len R.¹,Hawkins Phillip T.¹

Affiliation:

1. Inositide Laboratory, The Babraham Institute, Cambridge CB22 3AT, UK.

2. Department of Dermatology, University of Lübeck, 23538 Lübeck, Germany.

3. Department of Dermatology and Centre for Biological Signaling Studies, University of Freiburg, 79104 Freiburg, Germany.

4. Department of Physiology, Semmelweis University School of Medicine, P.O. Box 259, 1444 Budapest, Hungary.

5. Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Cambridge CB22 3AT, UK.

6. Department of Dermatology, University Medical Centre, 79104 Freiburg, Germany.

7. Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK.

8. Centre for Cell Signaling, Institute of Cancer, Queen Mary University of London, London EC1M 6BQ, UK.

Abstract

The β isoform of phosphoinositide 3-kinase may be an effective therapeutic target in inflammatory diseases.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference59 articles.

1. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

2. The emerging mechanisms of isoform-specific PI3K signalling

3. Signalling through Class I PI3Ks in mammalian cells

4. Targeting phosphoinositide 3-kinase—Moving towards therapy

5. PI3Kγ inhibition: towards an 'aspirin of the 21st century'?

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