Large-Scale Discovery of ERK2 Substrates Identifies ERK-Mediated Transcriptional Regulation by ETV3-Reference-Cited by-同舟云学术

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Large-Scale Discovery of ERK2 Substrates Identifies ERK-Mediated Transcriptional Regulation by ETV3

Published:2011-10-25 Issue:196 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Carlson Scott M.¹²,Chouinard Candace R.¹,Labadorf Adam¹,Lam Carol J.¹,Schmelzle Katrin¹,Fraenkel Ernest¹³,White Forest M.¹²

Affiliation:

1. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Koch Institute for Integrative Cancer Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

A chemical genetics strategy identified 67 previously unknown substrates of the kinase ERK2, including the transcriptional repressor ETV3.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference46 articles.

1. Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human

2. Role of MAPKs in development and differentiation: lessons from knockout mice

3. The role of MAPKs in adipocyte differentiation and obesity

4. MAP Kinases in the Immune Response

5. A clustered plasticity model of long-term memory engrams

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