The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier-Reference-Cited by-同舟云学术

The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier

Published:2010-12-21 Issue:153 Volume:3 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sturm Oliver E.¹,Orton Richard¹,Grindlay Joan²,Birtwistle Marc³,Vyshemirsky Vladislav¹,Gilbert David¹,Calder Muffy¹,Pitt Andrew⁴,Kholodenko Boris³,Kolch Walter³⁵

Affiliation:

1. Department of Computing Science, University of Glasgow, Glasgow G12 8QQ, UK.

2. Signalling and Proteomics Laboratory, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

3. Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

4. Sir Henry Wellcome Functional Genomics Facility, University of Glasgow, Glasgow G12 8QQ, UK.

5. Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.

Abstract

Analysis of ERK pathway circuitry suggests appropriate targets for inhibition, providing a guide for drug development.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference32 articles.

1. Differential regulation and properties of MAPKs

2. Mathematical Models of Protein Kinase Signal Transduction

3. Quantitative analysis of signaling networks

4. M. A. Savageau Biochemical Systems Analysis. A Study of Function and Design in Molecular Biology (Addison-Wesley Pub. Co. Reading MA 1976).

5. Coordinating ERK/MAPK signalling through scaffolds and inhibitors

Cited by 218 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Interference with Systemic Negative Feedback Regulation as a Potential Mechanism for Nonmonotonic Dose-Responses of Endocrine-Disrupting Chemicals;2024-09-08

2. Cell State Transition Models Stratify Breast Cancer Cell Phenotypes and Reveal New Therapeutic Targets;Cancers;2024-06-27

3. Importance of targeting various cell signaling pathways in solid cancers;International Review of Cell and Molecular Biology;2024

4. Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies;Signal Transduction and Targeted Therapy;2023-12-18

5. A guide to ERK dynamics, part 1: mechanisms and models;Biochemical Journal;2023-12-01