Coordinating ERK/MAPK signalling through scaffolds and inhibitors
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nrm1743.pdf
Reference109 articles.
1. O'Neill, E. & Kolch, W. Conferring specificity on the ubiquitous Raf/MEK signalling pathway. Br. J. Cancer 90, 283–288 (2004).
2. Wellbrock, C., Karasarides, M. & Marais, R. The RAF proteins take centre stage. Nature Rev. Mol. Cell Biol. 5, 875–885 (2004).
3. Chong, H., Vikis, H. G. & Guan, K. L. Mechanisms of regulating the Raf kinase family. Cell Signal. 15, 463–469 (2003).
4. Huser, M. et al. MEK kinase activity is not necessary for Raf-1 function. EMBO J. 20, 1940–1951 (2001).
5. Mikula, M. et al. Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J. 20, 1952–1962 (2001). References 4 and 5 describe the phenotype of Raf -1 knockout mice, demonstrating that some of the functions of Raf-1 are independent of its ability to activate the ERK/MAPK pathway.
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