p38α signaling in Langerhans cells promotes the development of IL-17–producing T cells and psoriasiform skin inflammation-Reference-Cited by-同舟云学术

p38α signaling in Langerhans cells promotes the development of IL-17–producing T cells and psoriasiform skin inflammation

Published:2018-03-13 Issue:521 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Zheng Tingting¹^ORCID,Zhao Weiheng¹^ORCID,Li Hongjin¹^ORCID,Xiao Shuxiu¹,Hu Ran¹,Han Miaomiao²,Liu Heng³,Liu Yeqiang⁴,Otsu Kinya⁵⁶^ORCID,Liu Xinguang³,Huang Gonghua¹^ORCID

Affiliation:

1. Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

2. Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

3. Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, China.

4. Shanghai Skin Disease Hospital, Tongji University, Shanghai 200443, China.

5. Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.

6. Cardiovascular Division, King’s College London, London WC2R 2LS, UK.

Abstract

Activation of p38α signaling in Langerhans cells, but not in other DC subsets or T cells, controls the development of psoriasis.

Funder

National Natural Science Foundation of China

Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning

Ministry of Science & Technology of China

Shanghai Sailing Program

Shanghai Municipal Commission of Health and Family Planning Grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference54 articles.

1. Pathogenesis and therapy of psoriasis

2. Psoriasis

3. Immunology of Psoriasis

4. The immunogenetics of Psoriasis: A comprehensive review

5. Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

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