Attractor Landscape Analysis Reveals Feedback Loops in the p53 Network That Control the Cellular Response to DNA Damage-Reference-Cited by-同舟云学术

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Attractor Landscape Analysis Reveals Feedback Loops in the p53 Network That Control the Cellular Response to DNA Damage

Published:2012-11-20 Issue:251 Volume:5 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Choi Minsoo¹,Shi Jue²,Jung Sung Hoon¹³,Chen Xi²,Cho Kwang-Hyun¹

Affiliation:

1. Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea.

2. Center for Quantitative Systems Biology and Department of Physics, Hong Kong Baptist University, Hong Kong, China.

3. Department of Information and Communication Engineering, Hansung University, Seoul 136-792, Republic of Korea.

Abstract

State-space analysis of the p53 network identifies a therapeutic strategy for treating cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference107 articles.

1. Initiating Cellular Stress Responses

2. Tumour suppression by p53: a role for the DNA damage response?

3. Tumor Suppressive Functions of p53

4. Oscillations by the p53-Mdm2 Feedback Loop

5. Dynamics of the p53-Mdm2 feedback loop in individual cells

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