Tumour suppression by p53: a role for the DNA damage response?
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
http://www.nature.com/articles/nrc2716.pdf
Reference164 articles.
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3. Vousden, K. H. & Lane, D. P. p53 in health and disease. Nature Rev. Mol. Cell Biol. 8, 275–283 (2007). This review provides a broad update on our understanding of p53 function, highlighting more recent discoveries that include the contribution of p53 under normal, unstressed, physiological conditions to processes, such as development, ageing and metabolism. It also discusses p53 as a target for therapeutic intervention.
4. Donehower, L. A. et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215–221 (1992).
5. Harvey, M. et al. A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice. Nature Genet. 9, 305–311 (1995).
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