Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation-Reference-Cited by-同舟云学术

Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation

Published:2021-06-22 Issue:688 Volume:14 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Minnis-Lyons Sarah E.¹^ORCID,Ferreira-González Sofía¹^ORCID,Aleksieva Niya¹^ORCID,Man Tak Yung¹^ORCID,Gadd Victoria L.¹^ORCID,Williams Michael J.¹^ORCID,Guest Rachel V.²^ORCID,Lu Wei-Yu³^ORCID,Dwyer Benjamin J.¹^ORCID,Jamieson Tam⁴^ORCID,Nixon Colin⁴^ORCID,Van Hul Noemi⁵^ORCID,Lemaigre Frederic P.⁶,McCafferty John⁷^ORCID,Leclercq Isabelle A.⁸^ORCID,Sansom Owen J.⁴⁹^ORCID,Boulter Luke¹⁰^ORCID,Forbes Stuart J.¹^ORCID

Affiliation:

1. Centre for Regenerative Medicine, Scottish Centre for Regenerative Medicine, Edinburgh, UK.

2. Clinical Surgery, Royal Infirmary of Edinburgh and University of Edinburgh, Edinburgh, UK.

3. Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

4. Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK.

5. Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.

6. Université catholique de Louvain, de Duve Institute, Brussels, Belgium.

7. IONTAS Ltd., Iconix Park, London Road, Pampisford, Cambridgeshire, UK.

8. Laboratory of Gastroenterology, Université Catholique de Louvain, Brussels, Belgium.

9. Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, UK.

10. MRC Human Genetics Unit, Institute of Genetics and Cancer, Edinburgh, UK.

Abstract

Notch signaling promotes progenitor cell proliferation but inhibits hepatocyte differentiation during liver repair.

Funder

Wellcome

Medical Research Council

Leverhulme Trust

Cancer Research UK

Belgian Science Policy

frs-fnrs

Fondation contre le Cancer

Belgian Federal Science Policy Office

PSC Support

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference47 articles.

1. Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

2. Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

3. Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver

4. Kupffer Cells Influence Parenchymal Invasion and Phenotypic Orientation, but Not the Proliferation, of Liver Progenitor Cells in a Murine Model of Liver Injury

5. Accumulation of Hedgehog-Responsive Progenitors Parallels Alcoholic Liver Disease Severity in Mice and Humans

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