Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development-Reference-Cited by-同舟云学术

Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

Published:2008-09-09 Issue:36 Volume:1 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Ciraolo Elisa¹,Iezzi Manuela²,Marone Romina³,Marengo Stefano¹,Curcio Claudia⁴,Costa Carlotta¹,Azzolino Ornella¹,Gonella Cristiano¹,Rubinetto Cristina¹,Wu Haiyan⁵,Dastrù Walter⁶,Martin Erica L.⁷,Silengo Lorenzo¹,Altruda Fiorella¹,Turco Emilia¹,Lanzetti Letizia⁸,Musiani Piero²,Rückle Thomas⁹,Rommel Christian⁹,Backer Jonathan M.⁵,Forni Guido⁴,Wymann Matthias P.³,Hirsch Emilio¹

Affiliation:

1. Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.

2. Aging Research Centre, G. d’Annunzio University Foundation, 66013 Chieti, Italy.

3. Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland.

4. Department of Clinical and Biological Sciences, Molecular Biotechnology Center, University of Torino, via Nizza 52, 10126 Torino, Italy.

5. Department of Molecular Pharmacology, Albert Einstein College of Medicine, 10461 Bronx, NY, USA.

6. Department of Chemistry IFM, Molecular Imaging Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.

7. Department of Anesthesia and Critical Care, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy.

8. Dipartimento di Scienze Oncologiche, Istituto per la Ricerca e la Cura del Cancro, University of Torino, Strada Provinciale 142, 10060 Candiolo, Torino, Italy.

9. Merck Serono S.A., Geneva Research Center, CH-1202 Geneva, Switzerland.

Abstract

The phosphoinositide 3-kinase p110β subunit has noncatalytic functions; its catalytic activity is pertinent to both diabetes and cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference37 articles.

1. Phosphoinositide 3-kinase in disease: timing, location, and scaffolding

2. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

3. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling

4. Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

5. A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

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