The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4 + T cells-Reference-Cited by-同舟云学术

The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4 + T cells

Published:2018-07-10 Issue:538 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Gaud Guillaume¹^ORCID,Roncagalli Romain²^ORCID,Chaoui Karima³,Bernard Isabelle¹^ORCID,Familiades Julien¹,Colacios Céline¹,Kassem Sahar¹,Monsarrat Bernard³,Burlet-Schiltz Odile³,de Peredo Anne Gonzalez³^ORCID,Malissen Bernard²⁴,Saoudi Abdelhadi¹^ORCID

Affiliation:

1. Centre de Physiopathologie de Toulouse Purpan, Université de Toulouse, CNRS, Inserm, Toulouse 31300, France.

2. Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université, Inserm, CNRS, 13288 Marseille, France.

3. Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS UMR 5089, 31077 Toulouse Cedex, France.

4. Centre d’Immunophénomique, Aix-Marseille Université, Inserm, CNRS, 13288 Marseille, France.

Abstract

VAV1 mediates cross-talk between the CD226 and TCR signaling pathways to enhance production of the proinflammatory cytokine IL-17.

Funder

Fondation d’Aide pour la Recherche sur la Sclerose en Plaques

Association Francaise contre les Myopathies

FP7 Health

European Research Council

Agence Nationale de la Recherche

Fondation pour la Recherche Médicale

Région Pyrénées

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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4. Function of the Nucleotide Exchange Activity of Vav1 in T Cell Development and Activation

5. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

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