Function of the Nucleotide Exchange Activity of Vav1 in T Cell Development and Activation-Reference-Cited by-同舟云学术

Function of the Nucleotide Exchange Activity of Vav1 in T Cell Development and Activation

Published:2009-12-15 Issue:101 Volume:2 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Saveliev Alexander¹,Vanes Lesley¹,Ksionda Olga¹,Rapley Jonathan¹²,Smerdon Stephen J.²,Rittinger Katrin²,Tybulewicz Victor L. J.¹

Affiliation:

1. Division of Immune Cell Biology, MRC National Institute for Medical Research, London NW7 1AA, UK.

2. Division of Molecular Structure, MRC National Institute for Medical Research, London NW7 1AA, UK.

Abstract

The guanine nucleotide exchange activity of Vav1 is required for some, but not all, of its functions in T cell development, activation, and signaling.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference60 articles.

1. Regulatory and Signaling Properties of the Vav Family

2. Rho family GTPases and their regulators in lymphocytes

3. Crucial structural role for the PH and C1 domains of the Vav1 exchange factor

4. Essential Role of Vav Family Guanine Nucleotide Exchange Factors in EphA Receptor-Mediated Angiogenesis

5. Vav Family GEFs Link Activated Ephs to Endocytosis and Axon Guidance

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