Synergistically acting agonists and antagonists of G protein–coupled receptors prevent photoreceptor cell degeneration-Reference-Cited by-同舟云学术

Synergistically acting agonists and antagonists of G protein–coupled receptors prevent photoreceptor cell degeneration

Published:2016-07-26 Issue:438 Volume:9 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Chen Yu¹²,Palczewska Grazyna³,Masuho Ikuo⁴,Gao Songqi²,Jin Hui²,Dong Zhiqian³,Gieser Linn⁵,Brooks Matthew J.⁵,Kiser Philip D.²⁶,Kern Timothy S.²⁶⁷,Martemyanov Kirill A.⁴,Swaroop Anand⁵,Palczewski Krzysztof²³

Affiliation:

1. Yueyang Hospital and Clinical Research Institute of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.

2. Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

3. Polgenix Inc., Cleveland, OH 44106, USA.

4. Department of Neuroscience, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.

5. Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.

6. Research Service, Louis Stokes Cleveland VA Medical Center, Cleveland, OH 44106, USA.

7. Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

Abstract

Systems pharmacology reveals a combination of GPCR-targeted drugs that prevent retinal degeneration.

Funder

NIH

National Natural Science Foundation of China

Department of Veterans Affairs

Intramural Research Program of the National Eye Institute

Arnold and Mabel Beckman Foundation

Canadian Institute for Advanced Research

John H. Hord Professor of Pharmacology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference64 articles.

1. Systems Pharmacology: An opinion on how to turn the impossible into grand challenges

2. Systems pharmacology of complex diseases

3. Complex diseases require complex therapies

4. Developing New Drug Treatments in the Era of Network Medicine

5. Systems Pharmacology of Adverse Event Mitigation by Drug Combinations

Cited by 35 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models;Nature Communications;2024-07-15

2. Synthesis and Biological Analysis of Iso-dimethyltryptamines in a Model of Light-Induced Retinal Degeneration;ACS Medicinal Chemistry Letters;2024-06-13

3. Melanopsin-mediated optical entrainment regulates circadian rhythms in vertebrates;Communications Biology;2023-10-18

4. Single Cell RNA Sequencing Analysis of Mouse Retina Identifies a Subpopulation of Muller Glia Involved in Retinal Recovery From Injury in the FCD-LIRD Model;Investigative Opthalmology & Visual Science;2023-08-01

5. Ginsenoside Re Mitigates Photooxidative Stress-Mediated Photoreceptor Degeneration and Retinal Inflammation;Journal of Neuroimmune Pharmacology;2023-06-16