Systems Pharmacology of Adverse Event Mitigation by Drug Combinations-Reference-Cited by-同舟云学术

Systems Pharmacology of Adverse Event Mitigation by Drug Combinations

Published:2013-10-09 Issue:206 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhao Shan¹²,Nishimura Tomohiro¹³,Chen Yibang¹²,Azeloglu Evren U.¹²,Gottesman Omri⁴⁵,Giannarelli Chiara⁵⁶,Zafar Mohammad U.⁵⁶,Benard Ludovic⁶,Badimon Juan J.⁵⁶,Hajjar Roger J.⁴⁵⁶,Goldfarb Joseph¹,Iyengar Ravi¹²

Affiliation:

1. Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

2. Systems Biology Center New York, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

3. Division of Pharmaceutics, Faculty of Pharmacy, Keio University, Tokyo 105-8512, Japan.

4. Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

5. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

6. Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Abstract

Drug combinations that mitigate adverse events were identified using the FDA Adverse Event Reporting System, and one combination, exenatide and rosiglitazone, was tested in a rodent model.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference27 articles.

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2. Mapping Adverse Drug Reactions in Chemical Space

3. Moving towards individualized medicine with pharmacogenomics

4. Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data

5. Network analysis of FDA approved drugs and their targets

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