The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps

Author:

Apel Falko12ORCID,Andreeva Liudmila345,Knackstedt Lorenz Sebastian126ORCID,Streeck Robert12ORCID,Frese Christian Karl7ORCID,Goosmann Christian12,Hopfner Karl-Peter3,Zychlinsky Arturo12ORCID

Affiliation:

1. Max Planck Institute for Infection Biology, Department of Cellular Microbiology, Charitéplatz 1, 10117 Berlin, Germany.

2. Department of Biology, Humboldt University, Charitéplatz 1, 10117 Berlin, Germany.

3. Gene Center, Ludwig-Maximillians-Universität München, Feodor-Lynen-Straße 25, 81377 Munich, Germany.

4. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

5. Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115, USA.

6. T-Knife GmbH, Robert-Rössle-Straße 10, 13125 Berlin, Germany.

7. Max Planck Unit for the Science of Pathogens, Charitéplatz 1, 10117 Berlin, Germany.

Abstract

Upon phagocytosis by macrophages, components of neutrophil extracellular traps stimulate type I interferon production.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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