Systematic identification of signaling pathways with potential to confer anticancer drug resistance-Reference-Cited by-同舟云学术

Systematic identification of signaling pathways with potential to confer anticancer drug resistance

Published:2014-12-23 Issue:357 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Martz Colin A.¹,Ottina Kathleen A.²³,Singleton Katherine R.¹,Jasper Jeff S.¹,Wardell Suzanne E.¹,Peraza-Penton Ashley¹,Anderson Gray R.¹,Winter Peter S.¹,Wang Tim²³⁴,Alley Holly M.¹,Kwong Lawrence N.⁵,Cooper Zachary A.⁵,Tetzlaff Michael⁵,Chen Pei-Ling⁵,Rathmell Jeffrey C.¹,Flaherty Keith T.⁶,Wargo Jennifer A.⁵,McDonnell Donald P.¹,Sabatini David M.²³⁴,Wood Kris C.¹

Affiliation:

1. Department of Pharmacology and Cancer Biology, Duke University, 450 Research Drive, Durham, NC 27710, USA.

2. Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

3. Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

4. Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.

5. University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

6. Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston, MA 02114, USA.

Abstract

Pathway-centric screening reveals new mechanisms of drug resistance and combination therapeutic strategies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference48 articles.

1. Converting Cancer Therapies into Cures: Lessons from Infectious Diseases

2. Mechanisms of Autoinhibition and STI-571/Imatinib Resistance Revealed by Mutagenesis of BCR-ABL

3. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

4. MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

5. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

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