Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes

Author:

Jafari Naser1ORCID,Kolla Manohar1ORCID,Meshulam Tova2,Shafran Jordan S.1ORCID,Qiu Yuhan1ORCID,Casey Allison N.1,Pompa Isabella R.1ORCID,Ennis Christina S.1ORCID,Mazzeo Carla S.3ORCID,Rabhi Nabil2ORCID,Farmer Stephen R.2ORCID,Denis Gerald V.145ORCID

Affiliation:

1. Boston University–Boston Medical Center Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA.

2. Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.

3. Section of Gastroenterology, Boston University School of Medicine, Boston, MA 02118, USA.

4. Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA.

5. Shipley Prostate Cancer Research Professor, Boston University School of Medicine, Boston, MA 02118, USA.

Abstract

Exosomes from insulin-resistant adipocytes induce changes in breast cancer cells that promote metastasis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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