Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins

Author:

Wilhelm Isabel123ORCID,Levit-Zerdoun Ella456ORCID,Jakob Johanna7ORCID,Villringer Sarah13,Frensch Marco135ORCID,Übelhart Rudolf7,Landi Alessia13ORCID,Müller Peter13ORCID,Imberty Anne8ORCID,Thuenauer Roland13,Claudinon Julie13,Jumaa Hassan7ORCID,Reth Michael134,Eibel Hermann910,Hobeika Elias7ORCID,Römer Winfried123ORCID

Affiliation:

1. Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.

2. Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany.

3. Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.

4. Max Planck Institute of Immunology and Epigenetics Freiburg, 79108 Freiburg, Germany.

5. International Max Planck Research School (IMPRS), Max Planck Institute of Immunobiology and Epigenetics Freiburg, 79108 Freiburg, Germany.

6. German Cancer Consortium (DKTK) partner site Freiburg, German Cancer Center (DKFZ), Heidelberg, Institute of Molecular Medicine and Cell Research, 79104 Freiburg, Germany.

7. Institute for Immunology, University Medical Centre Ulm, 89081 Ulm, Germany.

8. Univ. Grenoble Alpes, CNRS, CERMAV, 38000 Grenoble, France.

9. CCI-Center for Chronic Immunodeficiency (CCI), University Medical Centre, 79106 Freiburg, Germany.

10. Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Abstract

Fucose-specific bacterial lectins bind to and stimulate mouse B cells, inducing an immune response in vivo.

Funder

European Research Council

German Research Foundation

Federal Ministry of Education and Research

Ministry of Science, Research and the Arts Baden Württemberg

French National Research Agency

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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