The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo-Reference-Cited by-同舟云学术

The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo

Published:2017-02-21 Issue:467 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Liu Caini¹^ORCID,Zhu Liang²³^ORCID,Fukuda Koichi²,Ouyang Suidong¹^ORCID,Chen Xing¹^ORCID,Wang Chenhui¹⁴,Zhang Cun-jin¹⁵,Martin Bradley¹,Gu Chunfang¹,Qin Luke¹^ORCID,Rachakonda Suguna⁶,Aronica Mark⁷,Qin Jun²³,Li Xiaoxia¹^ORCID

Affiliation:

1. Department of Immunology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

2. Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

3. Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

4. Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

5. Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.

6. National Institutes of Health Center for Accelerated Innovations, Cleveland Clinic, Cleveland, OH 44195, USA.

7. Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Abstract

A molecule from red berries blocks the activity of a proinflammatory cytokine and alleviates inflammation in mice.

Funder

National Institutes of Health

National Multiple Sclerosis Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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