G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness-Reference-Cited by-同舟云学术

G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness

Published:2012-12-04 Issue:253 Volume:5 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Dbouk Hashem A.¹,Vadas Oscar²,Shymanets Aliaksei³,Burke John E.²,Salamon Rachel S.¹,Khalil Bassem D.¹,Barrett Mathew O.⁴,Waldo Gary L.⁴,Surve Chinmay⁵,Hsueh Christine⁶,Perisic Olga²,Harteneck Christian³,Shepherd Peter R.⁷,Harden T. Kendall⁴,Smrcka Alan V.⁵,Taussig Ronald⁸,Bresnick Anne R.⁶,Nürnberg Bernd³,Williams Roger L.²,Backer Jonathan M.¹

Affiliation:

1. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

2. MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

3. Department of Pharmacology and Experimental Therapy, Institute for Pharmacology and Toxicology and Interfaculty Center of Pharmacogenomics and Pharma Research Eberhard-Karls-Universität Tübingen, Tübingen 72074, Germany.

4. Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

5. Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

6. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

7. Department of Molecular Medicine and Pathology, University of Auckland, Auckland 1142, New Zealand.

8. Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Blocking the activation of p110β by G proteins inhibits tumor cell proliferation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference46 articles.

1. Targeting PI3K signalling in cancer: opportunities, challenges and limitations

2. Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit

3. Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers

4. PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes

5. Heterodimeric Phosphoinositide 3-Kinase Consisting of p85 and p110β Is Synergistically Activated by the βγ Subunits of G Proteins and Phosphotyrosyl Peptide

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