The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr 192-Reference-Cited by-同舟云学术

The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr 192

Author:

Granum Stine¹,Sundvold-Gjerstad Vibeke¹,Gopalakrishnan Ramakrishna Prabhu¹,Berge Tone²,Koll Lise¹,Abrahamsen Greger¹,Sørlie Morten³,Spurkland Anne¹

Affiliation:

1. Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.

2. Department of Neurology, Oslo University Hospital Ullevål, 0424 Oslo, Norway.

3. Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, 1432 Ås, Norway.

Abstract

Phosphorylation of a tyrosine residue in the SH2 domain of the kinase Lck alters its substrate specificity in T cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference76 articles.

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