Purinergic P2Y 6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II–induced hypertension-Reference-Cited by-同舟云学术

Purinergic P2Y 6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II–induced hypertension

Published:2016-01-19 Issue:411 Volume:9 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Nishimura Akiyuki¹²,Sunggip Caroline¹³⁴,Tozaki-Saitoh Hidetoshi⁵⁶,Shimauchi Tsukasa¹⁴,Numaga-Tomita Takuro¹²,Hirano Katsuya⁷,Ide Tomomi⁸,Boeynaems Jean-Marie⁹,Kurose Hitoshi¹⁰,Tsuda Makoto⁶,Robaye Bernard⁹,Inoue Kazuhide⁵,Nishida Motohiro¹²⁴¹¹

Affiliation:

1. Division of Cardiocirculatory Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences, Okazaki, Aichi 444-8787, Japan.

2. SOKENDAI (School of Life Science, The Graduate University for Advanced Studies), Hayama, Kanagawa 240-0193, Japan.

3. Department of Biomedical Science and Therapeutic, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah 88400 Malaysia.

4. Department of Translational Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

5. Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

6. Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

7. Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.

8. Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

9. Institute of Interdisciplinary Research, School of Medicine, Université Libre de Bruxelles, Gosselies 6041, Belgium.

10. Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

11. Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.

Abstract

Aging changes the response of blood vessels to angiotensin II, contributing to hypertension.

Funder

Japan Science and Technology Agency

Precursory Research for Embryonic Science and Technology Program

Grants-in-Aid for Scientific Research

Platform for Drug Discovery, Informatics, and Structural Life Science

Ministry of Education, Culture, Sports, Science and Technology, Japan

Kimura Memorial Heart Foundation

Daiko Foundation

Novartis Foundation (Japan) for the Promotion of Science

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference57 articles.

1. Angiotensin II-Mediated Development of Vascular Diseases

2. Angiotensin-Converting Enzyme and Vascular Remodeling

3. Angiotensin II Type 1 Receptor Blockade Attenuates In-Stent Restenosis by Inhibiting Inflammation and Progenitor Cells

4. Angiotensin II Stimulates Platelet-Derived Growth Factor-B Chain Expression in Newborn Rat Vascular Smooth Muscle Cells and Neointimal Cells Through Ras, Extracellular Signal–Regulated Protein Kinase, and c-Jun N-Terminal Protein Kinase Mechanisms

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