Distinct Phosphorylation Sites on the β 2 -Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin-Reference-Cited by-同舟云学术

Distinct Phosphorylation Sites on the β 2 -Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin

Published:2011-08-09 Issue:185 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Nobles Kelly N.¹,Xiao Kunhong²,Ahn Seungkirl²,Shukla Arun K.²³,Lam Christopher M.²,Rajagopal Sudarshan²,Strachan Ryan T.²,Huang Teng-Yi²,Bressler Erin A.²,Hara Makoto R.²,Shenoy Sudha K.²⁴,Gygi Steven P.⁵,Lefkowitz Robert J.¹²³

Affiliation:

1. Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.

2. Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

3. Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.

4. Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

5. Department of Cell Biology, Harvard University Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

Abstract

Different patterns of GPCR phosphorylation produce distinct conformations of β-arrestin and specific downstream responses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference44 articles.

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5. -Blockers alprenolol and carvedilol stimulate -arrestin-mediated EGFR transactivation

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