A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction-Reference-Cited by-同舟云学术

A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction

Published:2011-09-06 Issue:189 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Vinayagam Arunachalam¹,Stelzl Ulrich¹²,Foulle Raphaele¹,Plassmann Stephanie¹,Zenkner Martina¹,Timm Jan¹,Assmus Heike E.³,Andrade-Navarro Miguel A.¹,Wanker Erich E.¹

Affiliation:

1. AG Neuroproteomics and Computational Biology and Data Mining Group, Max Delbrück Centrum for Molecular Medicine, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany.

2. Otto-Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, D-14195 Berlin, Germany.

3. AG Systems Biology and Bioinformatics, Department of Computer Science, University of Rostock, Ulmenstrasse 69, D-18051 Rostock, Germany.

Abstract

Effective prediction of the direction of signal flow in an interaction network enables modeling of signaling dynamics and identification of regulatory proteins.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference68 articles.

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4. Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: Implications for cancer therapy

5. Coordinating ERK/MAPK signalling through scaffolds and inhibitors

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