BRAF-induced tumorigenesis is IKKα-dependent but NF-κB–independent-Reference-Cited by-同舟云学术

BRAF-induced tumorigenesis is IKKα-dependent but NF-κB–independent

Published:2015-04-21 Issue:373 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Margalef Pol¹,Colomer Carlota¹,Villanueva Alberto²,Montagut Clara³,Iglesias Mar⁴,Bellosillo Beatriz⁴,Salazar Ramón⁵,Martínez-Iniesta María²,Bigas Anna¹,Espinosa Lluís¹

Affiliation:

1. Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Parc de Recerca Biomèdica de Barcelona, Barcelona 08003, Spain.

2. Laboratori de Recerca Translacional, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), Institut Català d’Oncologia, Gran Via km 2.7, Hospitalet, Barcelona 08907, Spain.

3. Department of Oncology, IMIM, Universitat Pompeu Fabra, Barcelona 08003, Spain.

4. Department of Pathology, IMIM, Barcelona 08003, Spain.

5. Department of Oncology, Hospital de Bellvitge, Hospitalet, Barcelona 08907, Spain.

Abstract

Disrupting endosome function may inhibit mutant BRAF–mediated colon cancer growth.

Funder

Instituto de Salud Carlos III-FEDER

AGAUR

RTICCS/FEDER

Publisher

American Association for the Advancement of Science (AAAS)

Subject