Design and Synthesis of Novel Aminoindazole-pyrrolo[2,3-b]pyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling
Author:
Affiliation:
1. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK
2. Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK
Abstract
Funder
Cancer Research UK Discovery Award
Prostate Cancer UK Project Award
Publisher
MDPI AG
Link
https://www.mdpi.com/1420-3049/29/15/3515/pdf
Reference62 articles.
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3. Prescott, J.A., and Cook, S.J. (2018). Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors. Cells, 7.
4. Paul, A., Edwards, J., Pepper, C., and Mackay, S. (2018). Inhibitory-ΚB Kinase (IKK) α and Nuclear Factor-ΚB (NFκB)-Inducing Kinase (NIK) as Anti-Cancer Drug Targets. Cells, 7.
5. NF-ΚB, Inflammation, Immunity and Cancer: Coming of Age;Taniguchi;Nat. Rev. Immunol.,2018
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