Interleukin-11 Links Oxidative Stress and Compensatory Proliferation

Author:

Nishina Takashi12,Komazawa-Sakon Sachiko1,Yanaka Saeko3,Piao Xuehua1,Zheng Dong-Mei45,Piao Jiang-Hu156,Kojima Yuko7,Yamashina Shunhei8,Sano Emiko39,Putoczki Tracy10,Doi Takahiro11,Ueno Takashi4,Ezaki Junji4,Ushio Hiroko2,Ernst Matthias10,Tsumoto Kouhei39,Okumura Ko12,Nakano Hiroyasu1

Affiliation:

1. Department of Immunology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

2. Atopy Research Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

3. Department of Medical Genome Sciences, School of Frontier Sciences, University of Tokyo, Kashiwa 277-8562, Japan.

4. Department of Biochemistry, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

5. Sportology Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

6. Department of Immunology, School of Basic Medical Science, Ningxia Medical College, 1160 Shengli Street, Xingqing-Qu, Yinchuan 750004, China.

7. Division of Biomedical Imaging Research, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

8. Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

9. The Institute of Medical Science, University of Tokyo, Kashiwa 277-8562, Japan.

10. Colon Molecular and Cell Biology Laboratory, Ludwig Institute for Cancer Research, PO Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia.

11. Subteam for BioResponse Integration, RIKEN (Institute of Physical and Chemical Research), BioResource Center, Tsukuba, Ibaraki 305-0074, Japan.

Abstract

In dying cells, reactive oxygen species stimulate the production of a cytokine that triggers the healthy neighboring cells to proliferate.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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