Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non–small cell lung cancer-Reference-Cited by-同舟云学术

Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non–small cell lung cancer

Published:2017-01-10 Issue:461 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Gamell Cristina¹²,Gulati Twishi¹²,Levav-Cohen Yaara³,Young Richard J.⁴,Do Hongdo⁵,Pilling Pat⁶,Takano Elena⁷,Watkins Neil⁸,Fox Stephen B.⁷,Russell Prudence⁹,Ginsberg Doron¹⁰,Monahan Brendon J.¹¹,Wright Gavin¹²¹³,Dobrovic Alex⁵,Haupt Sue¹²,Solomon Ben²⁴,Haupt Ygal¹²¹⁴¹⁵

Affiliation:

1. Tumour Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.

2. Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria 3000, Australia.

3. The Hebrew University Hadassah Medical School, Jerusalem 9112102, Israel.

4. Molecular Therapeutics and Biomarkers Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.

5. Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Victoria 3084, Australia.

6. Biomedical Manufacturing Program, Commonwealth Scientific and Industrial Research Organization, Melbourne, Victoria 3169, Australia.

7. Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.

8. The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.

9. Department of Anatomical Pathology, St. Vincent’s Hospital, Melbourne, Victoria 3065, Australia.

10. The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel.

11. Systems Biology and Personalised Medicine, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 2555, Australia.

12. Department of Surgery, St. Vincent’s Hospital, Melbourne, Victoria 3065, Australia.

13. Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.

14. Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia.

15. Department of Pathology, University of Melbourne, Victoria 3800, Australia.

Abstract

E6AP exhibits tumor suppressor activity that may help stratify NSCLC patients.

Funder

National Health and Medical Research Council

Cancer Council Victoria

Victorian Endowment for Science, Knowledge, and Innovation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference45 articles.

1. The Regulation of INK4/ARF in Cancer and Aging

2. Ink4-Arf locus in cancer and aging

3. Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all

4. Oncogenic activity of Cdc6 through repression of the INK4/ARF locus

5. Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F

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