Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nrm1987.pdf
Reference150 articles.
1. Gonzalez, S. et al. Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. Nature 440, 702–706 (2006). The authors identify an origin of DNA replication adjacent to the INK4b gene and show that it also functions as a regulatory domain for transcription. Loading of CDC6 or siRNA directed against the regulatory domain suppresses transcription from the entire INK4b–ARF–INK4a locus.
2. Valk-Lingbeek, M. E., Bruggeman, S. W. & van Lohuizen, M. Stem cells and cancer; the polycomb connection. Cell 118, 409–418 (2004).
3. Ruas, M. & Peters, G. The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim. Biophys. Acta 1378, F115–F177 (1998).
4. Sharpless, N. E. INK4a/ARF: a multifunctional tumor suppressor locus. Mutat. Res. 576, 22–38 (2005).
5. Kamb, A. et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science 264, 436–440 (1994).
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