Flexible adaptation of male germ cells from female iPSCs of endangered Tokudaia osimensis

Author:

Honda Arata12,Choijookhuu Narantsog3ORCID,Izu Haruna1,Kawano Yoshihiro1,Inokuchi Mizuho14,Honsho Kimiko1,Lee Ah-Reum1,Nabekura Hiroki1,Ohta Hiroshi56,Tsukiyama Tomoyuki7,Ohinata Yasuhide8,Kuroiwa Asato9,Hishikawa Yoshitaka3ORCID,Saitou Mitinori561011,Jogahara Takamichi4,Koshimoto Chihiro4

Affiliation:

1. Organization for Promotion of Tenure Track, University of Miyazaki, Miyazaki 889-1692, Japan.

2. RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074, Japan.

3. Department of Histochemistry and Cell Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan.

4. Division of Bio-Resources, Frontier Science Research Center, University of Miyazaki, Miyazaki 889-1692, Japan.

5. Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

6. Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO), Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

7. Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science, Seta, Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.

8. Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

9. Division of Reproductive and Developmental Biology, Department of Biological Sciences, Faculty of Science, Hokkaido University, Sapporo, Japan.

10. Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

11. Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Abstract

T okudaia osimensis exhibits high sexual plasticity, through which female somatic cells can be converted to male germline cells.

Funder

Program to Disseminate Tenure Tracking System from the Ministry of Education, Culture, Sports, Science and Technology

PRESTO of the Japan Science and Technology Agency; the Japan Science and Technology Agency

A Grant-in-Aid for Scientific Research

A Grant-in-Aid for Challenging Exploratory Research

Pro Natura Fund for Nansei Islands project

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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