Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction-Reference-Cited by-同舟云学术

Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction

Published:2016-01-29 Issue:6272 Volume:351 Page:514-516
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Yamauchi Yasuhiro¹,Riel Jonathan M.¹,Ruthig Victor A.¹,Ortega Eglė A.¹,Mitchell Michael J.²,Ward Monika A.¹

Affiliation:

1. Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, 1960 East-West Road, Honolulu, HI 96822, USA.

2. Aix-Marseille Université, INSERM, GMGF UMR_S 910, 13385 Marseille, France.

Abstract

Replacing the Y chromosome The mammalian Y chromosome encodes a specialized set of genes that are essential for male viability and fertility. In particular, the sex-determining region Y (SRY) protein is necessary to initiate male sex determination. However, Yamauchi et al. show that the functions of the entire Y chromosome can be replaced with only two genes. In mice, two transgenes, Sox9 and Eif2s3x , compensated for the absence of all Y chromosome genes to allow successful sperm formation. Science , this issue p. 514

Funder

NIH

Hawaii Community Foundation

INSERM

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference49 articles.

1. Two Y Genes Can Replace the Entire Y Chromosome for Assisted Reproduction in the Mouse

2. Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

3. Sox9 induces testis development in XX transgenic mice