Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method-Reference-Cited by-同舟云学术

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

Published:2017-06-02 Issue:6 Volume:3 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Aprile Francesco A.¹,Sormanni Pietro¹,Perni Michele¹,Arosio Paolo²,Linse Sara³^ORCID,Knowles Tuomas P. J.¹,Dobson Christopher M.¹,Vendruscolo Michele¹

Affiliation:

1. Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

2. Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland.

3. Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, 221 00 Lund, Sweden.

Abstract

A rational approach enables the almost complete suppression of nucleation events in Aβ42 aggregation using designed antibodies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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